孟刘坤

副主任医师 · 中国医学科学院阜外医院血管外科中心

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职称副主任医师
医院科室中国医学科学院阜外医院血管外科中心
擅长领域冠心病搭桥心脏瓣膜病成形及置换手术先天性心脏病的常规手术微创手术及介入封堵术心脏肿瘤及心包肿瘤切除术微创小切口心脏手术。1.冠心病：冠心病搭桥术。2.
收录时间2026-10-16
浏览次数2

个人简介

孟刘坤（副主任医师）就职于中国医学科学院阜外医院血管外科中心，擅长冠心病搭桥、心脏瓣膜病成形及置换手术、先天性心脏病的常规手术等。本页整理其个人简介、擅长领域与就诊信息，并附同院同科室医生，供就诊参考。

1. 中国医学科学院，阜外医院心脏外科，副教授，硕士生导师；

2. 北京协和医学院，外科学博士研究生，毕业后一直从事心脏血管外科的临床科研工作；

3. 擅长冠脉搭桥，心脏瓣膜成形及置换，先天性心脏病矫治及心脏肿瘤切除等心脏疾病的诊疗；

4. 目前共完成2000余例患者的各种手术。

科研成果

作为项目负责人主持6项科研基金，其中国家自然科学基金2项，北京市自然科学基金面上项目2项，北京协和医学院院所基金2项。参与国家973科技支撑计划课题的研究。目前发表论文20余篇。
[1]. Ting H, Junzhi Z, Ting Q, Zhongjun Z, Hun H, Chao Y, Yong C, Yiwen R, Liukun M. Compensatory roles of Protein Related to DAN and Cerberus (PRDC) decrease in pulmonary arterial hypertension. Int J Biol Sci 2022；18(6):2372-2391.（通讯作者）
[2]. Meng L, Yuan W, Chi H, Han R, Zhang Y, Pan X, Meng J, Liu Y, Song J, Zhong J, Liu X. Genetic deletion of CMG2 exacerbates systemic-to-pulmonary shunt-induced pulmonary arterial hypertension. FASEB J 2021;35(4):e21421.（第一作者）
[3]. Meng L, Teng X, Liu Y, Yang C, Wang S, Yuan W, Meng J, Chi H, Duan L, Liu X. Vital Roles of Gremlin-1 in Pulmonary Arterial Hypertension Induced by Systemic-to-Pulmonary Shunts. J Am Heart Assoc 2020;9(15):e016586. （第一作者）
[4]. Meng LK，Liu X, Teng X, Gu H, Yuan W, Meng J, Li J, Zheng Z, Wei Y, Hu S. Osteopontin plays important roles in pulmonary arterial hypertension induced by systemic-to-pulmonary shunt. FASEB J 2019;33(6):7236-7251.（第一作者）
[5]. Meng L, Liu X, Teng X, Yuan W, Duan L, Meng J, Li J, Zheng Z, Wei Y, Hu S. DAN plays important compensatory roles in systemic-to-pulmonary shunt associated pulmonary arterial hypertension. Acta Physiol (Oxf) 2019;226(3):e13263. （第一作者）
[6]. Xiaoyan Liu, Liukun Meng, Jun Li, Jian Meng, Xiao Teng, Haiyong Gu, Shengshou Hu, Yingjie Wei. Secretory clusterin in upregulated in rats with pulmonary arterial hypertension induced by systemic-to-pulmonary shunts and exerts important roles in pulmonary artery smooth muscle cells. Acta Physiol 2015;213:505-518. （共第一作者）
[7]. Liukun Meng, Xiaoyan Liu, Zhe Zheng, Jun Li, Jian Meng, Yingjie Wei, Shengshou Hu. Original rat model of highkinetic unilateral pulmonary hypertension surgically induced by combined surgery. J Thorac Cardiovasc Surg 2013;146(5):1220-1226.（第一作者）
[8]. Xiaoyan Liu, Liukun Meng, Qiang Shi, Shenghua Liu, Chuanjue Cui, Shengshou Hu, Yingjie Wei. Dermatopontin promotes adhesion, spreading and migration of cardiac fibroblasts in vitro. Matrix Biology 2013;32:23-31. (共第一作者)
[9]. Liukun Meng, Chenggui Liu. Gene therapies for pulmonary hypertension from experimental to beside aspects. Eur J Cardio-thorac Surg 2012;37(2):407-19. （第一作者）
[10]. Wang S, Wang S, Lai Y, Song Y, Cui H, Song C, Meng L, Zhu C, Wu R, Huang X. Midterm results of different treatment methods for myocardial bridging in patients after septal myectomy. J Card Surg. 2021;36(2):501-508.
[12]. Wang S, Cui H, Meng L, Wu R, Tang B, Zhu C, Yu Q, Huang X, Wang S. Effect of Septal Myectomy on Obstructive Sleep Apnoea Syndrome in Patients With Hypertrophic Obstructive Cardiomyopathy. Heart Lung Circ 2020;29(9):1366-1374.
[13]. Wang S, Cui H, Zhu C, Wu R, Meng L, Yu Q, Huang X, Xiao M, Wang S. Obstructive sleep anea causes impairment of the carotid artery in patients with hypertrophic obstructive cardiomyopathy. Respir Med 2019;150:107-112.
[14]. Wang S, Cui H, Song C, Zhu C, Wu R, Meng L, Yu Q, Huang X, Wang S. Obstructive sleep apnea is associated with nonsustained ventricular tachycardia in patients with hypertrophic obstructive cardiomyopathy. Heart Rhythm 2019;16(5):694-701.
[15]. Wang S, Cui H, Tang B, Zhu C, Meng L, Yu Q, Huang X, Wu R, Wang S. Mid-term outcomes of simultaneous coronary artery bypass graft surgery and septal myectomy in patients with hypertrophic obstructive cardiomyopathy: A case-controlled study. J Card Surg. 2019;34(3):103-109.
[16]. Cui C, Zhang H, Guo LN, Zhang X, Meng L, Pan X, Wei Y. Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFβ-p38MAPK pathway. Biosci Rep 2016;36(4):e00374.
[17]. Wang G, Liu X, Meng L, Liu S, Wang L, Li J, Cui C, Meng J, Hu S, Wei Y. Up-regulated lipocalin-2 in pulmonary hypertension involving in pulmonary artery SMC resistance to apoptosis. Int J Biol Sci 2014;10(7):798-806.
[18]. Wang G, Liu S, Wang L, Meng L, Cui C, Zhang H, Hu S, Ma N, Wei Y. Lipocalin-2 Promotes Endoplasmic Reticulum Stress and Proliferation by Augmenting Intracellular Iron in Human Pulmonary Arterial Smooth Muscle Cells. Int J Biol Sci 2017;13(2):135-144.
[19]. Wang G, Ma N, Meng L, Wei Y, Gui J. Activation of the phosphatidylinositol 3-kinase/Akt pathway is involved in lipocalin-2-promoted human pulmonary artery smooth muscle cell proliferation. Mol Cell Biochem 2015;410(1-2):207-13.
[20]. 孟刘坤，滕晓，袁雯，孟健，李君，刘晓艳. 神经母细胞瘤抑瘤蛋白1在肺动脉高压大鼠中的表达变化.中国药理学通报 2019:35(9):1226-31.
[21]. 刘晓艳，孟刘坤，李君，魏英杰. 分泌型簇蛋白在肺动脉高压大鼠中的表达变化. 中国药理学通报 2014;30(6):764-768.